A win against one of their fiercest rivals could be huge in the title race.
Liverpool currently sit second in the Premier League table, four points behind Chelsea at the top. They currently sit level on points with Arsenal who are third - with the Reds having a superior goal difference - and two points ahead of Manchester City having played two games more.
Aldridge said in his Liverpool Echo column: "There is no doubt that the Reds are in the title race although Brendan and Stevie are trying to play it down.
"Manchester United are up next and if we go there and win – which we are capable of – then the title becomes a massive reality.
"But for the time being all Liverpool can concentrate on is doing the things that have got them into this position.
"We can’t get carried away but it would take a poor effort between now and the end of the season for Liverpool to not secure Champions League football.
"Sometimes an international break can interfere with a side’s momentum but this will only give Brendan more time to prepare for the trip to Old Trafford."
Liverpool's record at United has been poor since their 4-1 demolition of the side during the last season when Liverpool put together a serious title charge - where they fell four points short of United at the end of the season in 2009.
The Reds have lost every game since by just the one goal on every occasion - whether that has been in the league or in cup competitions on each of their last six visits to Old Trafford.
So if Liverpool were to leave with all three points in their next Premier League match, it will be another big bogey ground ticked off the list where they have won, following the Britannia Stadium and St Mary's where Liverpool have both won this campaign against Stoke City and Southampton respectively.