The Dutch striker is reportedly disgruntled at Old Trafford, and his apparent frustration showed on Tuesday night as he criticised the tactics and his team mates in a shock outburst from the 30-year-old.
His comments have upset many fans and even players, as Javier Hernandez posted a thinly-veiled response to the former Arsenal star on Instagram, saying "Without your team-mates you can't be somebody in football, always be thankful."
These developments are likely to intensify rumours of a potential return to the Emirates Stadium for van Persie, just two years after he turned his back on the club in order to win trophies, and duly clinched the Premier League title with United last season.
But despite Arsenal desperately needing to buy a striker in the summer, Dutch football expert Marcel van der Kraak told Talksport today that there is no chance he will return to the Gunners, or even leave United.
"The links to Arsenal are laughable. He’s very loyal and Van Persie is not the kind of player who moves around. The only reason he left Arsenal was because he wanted to win trophies. He didn’t think, at the time, that there was enough experience in the team to win trophies anytime soon at Arsenal," said van der Kraak.
“He was at Arsenal for eight years though and played most of his youth career at Feyenoord. He’s only had two clubs his whole career. I don’t think he’ll go back to Arsenal or leave Manchester United after just one season, in 20 years, where they don’t win a trophy," he added.
The news may be received in a number of different ways - after all, van Persie's comments are causing disruption within the camp at United, and what would the reaction from Red Devils fans be if it was Wayne Rooney having that kind of impact on the team? Similarly, Arsenal fans haven't forgiven van Persie for leaving the club in 2012, and his return would likely draw a mixed reaction from Gunners supporters.
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