Here are the sides Arsene Wenger and David Moyes have selected. Kick-off from the Emirates at 19:45 GMT.
Arsenal: Szczesny, Sagna, Mertesacker, Koscielny, Gibbs, Arteta, Wilshere, Rosicky, Ozil, Cazorla, Giroud
Subs: Fabianski, Jenkinson, Monreal, Ox, Podolski, Sanogo, Bendtner
Manchester United: De Gea, Rafael, Smalling, Vidic, Evra, Valencia, Cleverley, Carrick, Mata, Rooney, Van Persie
Subs: Lindegaard, Büttner, Ferdinand, Fellaini, Young, Hernandez, Januzaj
Arsenal go into this game looking to bounce back from a 5-1 hammering at the hands of Liverpool last weekend.
Arsene Wenger revealed yesterday that he saw that result as an ‘accident’ and revealed the side’s determination to get back on track for the Premier League title with three important points in front of their own fans.
As far as Manchester United boss David Moyes is concerned, he’s under huge pressure to get a result in this game.
United’s chances of finishing with Champions League football at the end of the season are hanging by a thread and this is a game that the champions really need to win if that’s to remain a possibility.
More dropped points against Fulham at the weekend have created that pressure for United’s players to stand up to.
image: © markusunger