United travel to the Emirates Stadium off the back of a bizarre game against Fulham, where the Red Devils fell behind early on and proceeded to dominate the game, sending a Premier League record 81 crosses into the box, and finally the pressure told with two goals in quick succession, only for Darren Bent to hit a stunning late equaliser and pile the pressure on manager David Moyes.
Meanwhile, Arsenal suffered their worst defeat of the season having been completely dismantled by Brendan Rodgers' Liverpool. The Gunners were 4-0 down inside 20 minutes at Anfield, losing 5-1 in the end. A terrible display from all players has many questioning Arsenal's title credentials, and bouncing back against United on Wednesday night is an absolute must for Arsene Wenger's side, particularly after watching Chelsea draw with West Bromwich Albion on Tuesday.
Arsenal have been very strong at home this season, losing just once, and that was on the opening day of the season as Aston Villa sprung a surprise with a 3-1 win at the Emirates Stadium. Since then, Arsenal have dropped just four points at home, making a trip to North London a daunting task for visiting teams, especially having conceded just six goals at home all season.
United, on the other hand, have been patchy wherever they play this season. They have lost their last two games on the road, falling to Stoke City and Chelsea in 2-1 and 3-1 defeats respectively. Before that though, United had won three away games in a row, seeing off Aston Villa, Hull City and Norwich City. Moyes certainly needs a response from his players tonight after yet another disappointing result, but can they get it against an Arsenal team that is so good at home?
The key for United may be new signing Juan Mata. The former Chelsea man moved to Old Trafford for £37.1m in January, and has an exceptional record against Arsenal. With four goals and two assists in just five games against Wenger's men, Mata will be looking to improve on that record and get United back on track, but ex-Gunners striker Robin van Persie will also need a big performance after struggling against Fulham on Sunday.
With United going through a transitional season it would be tough to expect them to arrive in North London and win, especially with Arsenal's home form being so impressive.
Coupled with Chelsea dropping points last night, there should be enough motivation for the Gunners to grab a win, which is why Wenger's side look the most likely to bounce back from their weekend horror show.