We take a look at five of the best games between the two clubs as they brace themselves for another potentially historic match.
5) Arsenal 1 - 3 Manchester United - 2009
United travelled to London with a 1-0 goal advantage from the first leg after a rare goal from John O'Shea put the Champions League holders in the driving seat, despite facing a tough Arsenal side away from home.
The game became a Cristiano Ronaldo masterclass, once again proving why he is one of the best players on the planet. Park Ji-Sung stung Arsenal in the first ten minutes with a goal, which were followed up by two brilliant Ronaldo goals, including this very memorable free-kick.
4) Manchester United 0 - 1 Arsenal
Arsenal won the Premier League title at Old Trafford in 2002, after a fairly unspectacular game that was decided by a Slyvain Wiltord 55th minute strike in what was the Frenchman's 100th appearance for Arsenal.
The FA Cup win the Saturday prior to this game made it Arsenal's second double in four years - A fantastic time for the club.
3) Manchester United 0 - 0 Arsenal - 2003
It's not often that a nil-nil draw will get into an archive for the best games, however, this was a spectacle that earned the name 'the battle of Old Trafford'.
The game was viciously fought by both sides, but the game hit fever pitch when Patrick Vieira was rightly sent off for lashing out at Ruud Van Nistelrooy. Despite the Dutch player trying to walk away from the embittered old pros at Arsenal, he found himself in the limelight once again when he overpowered a last minute penalty into the crossbar. When the final whistle went, Arsenal's team all crowded round pushing and crowding around Van Nistelrooy, who calmly walked a way while Ronaldo, Ferdinand and Neville held the Arsenal players back.
2) Manchester United 2 - 0 Arsenal - 2004
An unbeaten run that spanned for more than a season came crashing to a halt at Old Trafford as Ruud Van Nistelrooy and Wayne Rooney made sure United didn't make it to 50-games unbeaten.
A year on from the explosive 'battle of Old Trafford' Ruud Van Nistelrooy this time scored the penalty that sent United on their way to ending Arsenal's impressive run. A late Wayne Rooney secured the three points for United, however, a post-match food fight ended up with Sir Alex Ferguson having a pizza thrown at him.
The game was later dubbed 'The Battle of the Buffet.'
1) Manchester United 8 - 2 Arsenal - 2011
In a game that still keeps Arsenal fans awake at night, Manchester United inflicted the heaviest defeat Arsenal have has since 1896.
A truly jaw-dropping game which involved a Wayne Rooney hat-trick, Ashley Young brace and goals from Welbeck, Nani and Park Ji-Sung. Arsenal had no reply to their old rivals and after the game their the fans, players and management all looked equally despondent.
The game is often referred to as the darkest day in Arsene Wenger's 18-year reign in North London.
image: © wonker