Reuters reports that Scotland will hold a referendum in September on whether to end its 307-year union with England, with polls showing around 42% planning to vote against independence and 29% in favour.
Cable said the greater stability offered by Britain's established financial system and regulation would tempt the bank to move its base to England.
'I think if you were managing RBS you would almost certainly want to be in a domicile where your bank is protected against the risk of collapse,' Cable told a panel of lawmakers.
'I think they already have a substantial amount of their management in London and I would have thought that inevitably they would become a London bank.'
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image: © Mark Ramsey