Manuel Pellegrini's side ruthlessly capitalised on Arsenal's draw at Southampton a night earlier to beat a hapless Spurs 5-1.
Sergio Aguero began the rout, before going off at half-time with the score at 1-0.
The turning point was Danny Rose's red card, with Yaya Toure doubling the lead from the penalty spot early in the second half.
Edin Dzeko and Vincent Kompany added to the scoreline, with Stevan Jovetic scoring his first Premier League goal in between, with Tottenham's Capoue adding a consolation.
City now sit one point clear at the top of the table, and have beaten Spurs by an aggregate of 11-1 over the two games this season. They won 5-1 at the ground just two seasons ago.