Wins for Manchester United, Chelsea, Arsenal while Manchester City and Tottenham Hotspur are predicted to drop points.
Hull City v Chelsea: 0-1
If Hull continue where they left off against Chelsea on the opening day of the season they might just sneak a result here.
However, with a sickness bug ravaging the squad it is unlikely to be a Tigers outfit at 100% - so Chelsea should come through a tough encounter.
Cardiff v West Ham: 3-1
Cardiff boss Ole Gunnar Solskjaer takes charge of his first Premier League game as Bluebirds manager - and probably could not have picked better opposition.
West Ham travel to Wales in a woeful spell of form - losing in the FA and League Cup 5-0 and 6-0 to Nottingham Forest and Manchester City respectively.
So expect Cardiff to poor more misery on The Hammers - even if Andy Carroll makes a cameo.
Everton v Norwich: 2-1
This is just the sort of game Everton might slip up in - however it is hard to see it happening. Despite being without Phil Jagielka and Sylvain Distin Martinez must fancy his team to come out on top at home to Norwich.
Fulham v Sunderland: 2-2
Both teams have potentially fully-fit squads and this is a must win game for both considering the relegation battle they find themselves in.
However a score draw seems a likely outcome in this evenly contested match.
Southampton v West Brom: 3-0
Southampton could welcome back Artur Boruc to action - and it would be a timely return. For The Baggies it is the first game under new boss Pepe Mel, a manager Mauricio Pochettino will know all about from his time in La Liga.
With only a couple of days to sort out his new team - The Saints should take full advantage.
Tottenham v Crystal Palace: 1-1
This will be a closer game than it appears immediately on paper.
Tim Sherwood’s philosophy is just about the right type for Tony Pulis to pick apart.
I can see Palace coming away with something from this game - and not a good hiding.
Manchester United v Swansea: 3-2
Hell has no fury like Manchester United scorned. Well that might have once been the case but recently David Moyes has been struggling to rally his troops.
With Rooney out another dismal day at Old Trafford could be on cards.
But I am going to go with my gut instinct, and suggest United’s luck may change for a challenging home win.
Newcastle v Man City: 2-1
Time for City to be taken down a peg or two?
I think so, and who better for the job than The Toon Army.
Away from home they have not been great - and St James Park may prove the difference.
Stoke v Liverpool: 0-3
Jack Butland has his hands full for Stoke this weekend - being tasked with keeping out Luis Suarez is certainly a challenge in the wake of Asmir Begovic’s and Thomas Sorensen’s injury woes.
Will he do it? Maybe - but he can’t all day!
Aston Villa v Arsenal: 1-3
A return to the opening game of the season sees them face Villa - hoping to do the double on their rivals.
But Arsenal have grown as a unit since then - and should be able to overcome their first day demons at Villa Park.
image: © wonker