The Gunners, on the other hand, need only to avoid a three-goal reverse to book their place in the next round.
Napoli looked far from capable of inflicting such a defeat on Arsene Wenger's men when they fell 2-0 at the Emirates Stadium.
But the Partenopei's forwards have looked on better form since and Goran Pandev, who netted twice in three minutes against Udinese last weekend believes his partnership with Gonzalo Higuain can test their visitors.
"We want to cause trouble for the English team," Pandev said in today's press conference.
"We didn't do well in the first game and we want to make up for that. It's easy when you're playing alongside Higuain. I'm on good form and that has given me confidence.
"We know that it will be a very difficult game but we have prepared well and we have had an excellent Champions League campaign so far.
"It's important that we don't rush things. We know how good Arsenal are and we need to remember everything that the coach has told us."