Manchester United and David Moyes try to avoid a third consecutive home defeat.
Instead the Red Devils find themselves cut adrift in the Premier League and having already secured Champions League qualification with a game to spare.
It places the under-pressure boss in an interesting situation - He will want to change up his squad, rotate his options, but can't face another loss.
Opponents Shakhtar are fighting for their own qualification, needing a win - but United will be keen to finish top.
Here is how we are tipping Manchester United to line-up on Tuesday night:
Rafael Evans Smalling Buttner
Zaha Rooney Young
Uninspiring? Perhaps, but then that's how David Moyes has been all season. We expect Robin van Persie, Patrice Evra and Nemanja Vidic all to be rested, while Wayne Rooney should feature after missing the Newcasrle game with suspension at the weekend.
Danny Welbeck is in need of a goal since returning, and Javier Hernandez has failed to grasp his recent chances with Van Persie out injured.
Wilfried Zaha came off the bench against Newcastle at the weekend, showing Moyes is coming around to the idea of bringing him into the first team - and this is the ideal scenario for the boss to have a look at him.
We also anticipate a recall for Ashley Young, with Shinji Kagawa rested again after his recent hospital visit.
image: © Tom Brogan