Manchester United play at home against a Newcastle side that has been revitalised in the past few weeks, storming to 7th in the league.
Moyes has had to deal with a tirade of abuse from the aftermath of the Everton loss at Old Trafford, and will be determined to put it right against Pardew's men.
Robin Van Persie is unlikely to feature, as is Wayne Rooney in what could be a stitched up United side. Newcastle don't face many injury worries and will be going into the game full of confidence.
The loss of Wayne Rooney, if he doesn't play will be huge for Manchester United. I am backing Javier Hernandez to be the main man this weekend, pulling United back into the title fight in a tight home win.
Manchester City face a tough trip to the south coast and play a side that have lost just once at home this season, but arguably haven't faced a challenge as tough as Pellegrini's men.
Notoriously poor away from home this season, Manchester City have recorded just 7 points from 7 games on the road and I think they could face a similar frustration on Saturday.
Southampton do have injury worries for the match against Manchester City, whilst the City still have a pretty much superstar filled 11 to travel with.
I am backing a high scoring draw with Manchester City losing their footing in 3rd in the process.
And I will also back Crystal Palace to take another leap to survival under Tony Pulis beating opponents Cardiff City at Selhurst park.
image: © Ronnie Macdonald