To be played on Saturday 7th December 2013 at 15:00. Venue: St. Mary's Stadium, Southampton.
Odds: Southampton 17/4, Draw 14/5, Manchester City 3/4
Last season: 3-1
Preview & injury news
After an impressive start to the season, Southampton have lost three on the bounce going into this game which has coincided was their first set of real injury problems this season. Defeats away to Arsenal and Chelsea wouldn't have been surprising, but losing 3-2 at home to Aston Villa having had 77% possession will have been a disappointment. Manchester City go into this game having won three leagues matches on the bounce, scoring 12 goals in the process and despite their poor away record this season they managed to get all three points against West Brom at The Hawthorns.
On the injury front, Southampton are without their first two goalkeepers with Artur Boruc ruled out until mid-January with a fractured hand whilst Kelvin Davis has a back injury. Morgan Schneiderlin has a groin problem, Victor Wanyama is struggling with a calf injury whilst Gaston Ramirez has been suffering from illness. Nathaniel Clyne is also struggling a hamstring injury.
For City, Mateja Nastasic will be out until the Christmas period start to get a bit busier with a calf injury, whilst this game will come too soon for David Silva and Stevan Jovetic who also have calf problems, but could be available for City's last Champions League group game against Bayern Munich.
Jay Rodriguez is Southampton's top scorer in the league this season with five goals
Sergio Aguero is Manchester City's top scorer in the league this season with 11 goals
Southampton had 77% possession in their last league match, a 3-2 defeat at home to Aston Villa.
Manchester had 58% possession in their last league match, a 3-2 win away to West Bromwich Albion
5 players to watch
Jay Rodriguez - Now their top scorer this season, Rodriguez will perhaps be the home side's biggest goal threat against a City back four that has been unsettled so far this season. Even with Vincent Kompany back in the side, Rodriguez could definitely get some joy.
Yaya Toure - A menace even against the strongest midfielders, but with Southampton's looking a bit depleted, you'd expect Toure to have a lot of joy in the middle of the park, and some may fear for the Saints in this one.
Paulo Gazzaniga - With Southampton's first two goalkeepers ruled out, the responsibility falls to 21-year-old Gazzaniga to be the man to keep City at bay as the last lime of defence. Can he pull out an impressive performance here?
Sergio Aguero - Another game in midweek, another goal for Aguero. He keeps ticking along nicely on the goalscoring front an it would not be a surprise if he finds the net again at St Mary's.
Steven Davis - Having scored in last season's win over City, Davis will be looking to repeat the feat as Southampton look to shot City again. With so many central players ruled out, there will be a bit of pressure on Davis to step up to the mark.
Last time they met
Southampton 3-1 Manchester City, Premier League February 2013
This was the beginning of the end of Manchester City's title defence as revived Southampton under new boss Maurcio Pochettino produced a stunning result to humble the champions. The Saints started quickly and took an early lead when Jason Puncheon slotted home the rebound of a Jay Rodriguez shot after Gareth Barry had given the ball away. Southampton doubled their lead midway through the first half when Joe Hart should have done better with Rickie Lambert's shot after it fell between his legs, allowing Steven Davis to prod it over the line. Edin Dzeko replied for City just before the break but a horrible own goal from Barry compounded Manchester City's misery, and gave a famous victory to Southampton.