To be played on Wednesday 4th December 2013 at 19:45. Venue: Old Trafford, Manchester.
Last season: 2-0
Preview & injury news
It's the first time that David Moyes will come up against his old club after he swapped Merseyside for the pressure job at Manchester United whilst Roberto Martinez will taking a side to Old Trafford confident of doing some damage having scored seven goals in their past two games.
United are currently nine points off top of the table Arsenal going into this one having drawn each of their last two games 2-2, and will not want the task of overhauling in order to retain their crown to become any more difficult, whilst Everton are level on points with fourth placed Liverpool and looking as if they could be a real threat to the Champions League places this season. A good result at Old Trafford would certainly send out a serious message about Everton's ambitions this season.
On the injury front, there are still concerns over the fitness of Robin Van Persie who is struggling with a groin injury to go along with the long-term absentees in central midfielders Michael Carrick and Darren Fletcher.
For Everton, they're without left-back and Manchester United target Leighton Baines until at least the new year whilst there is no news on when Arouna Kone and Darron Gibson will make their return to the first team squad.
Wayne Rooney is Manchester United's top scorer in the league with eight goals this season.
Romelu Lukaku is Everton's top scorer in the league with eight goals this season.
Manchester United had 60% possession in their last league match, a 2-2 away at Tottenham Hotspur.
Everton had 54% possession in their last league match, a 4-0 win at home to Stoke City.
5 players to watch
Wayne Rooney - It's always fascinating to watch Rooney come up against the club that brought him through and awarded him his first professional contract. There is the added factor that Rooney is currently in very good form for Manchester United and could well to add to the four goals he has scored against his boyhood team in the past.
Romelu Lukaku - He may be locked in a war of words with the manager of his parent club at Chelsea, but Lukaku is in very good form for Everton at the moment having found the net eight times this season. Whichever central defensive partnership David Moyes selects, they are going to have a tough time with Lukaku - who also scored a hat-trick against Manchester United in Sir Alex Ferguson's last game in charge when Belgian was donning the colours of West Bromwich Albion.
Marouanne Fellaini - Fellaini made the switch from Goodison to Old Trafford shortly after David Moyes and so far his effect on the United side has been minimal. If selected, he will want to prove a point that he did make the right move and is worthy of a place in the starting line-up of the current Champions.
Gerard Deulofeu - The young Spaniard has proven in the past couple of games why he is a very exciting talent and was particularly impressive in the weekend's win against Stoke. It is a different task to perform to the same level at Old Trafford but it will be interesting to see if he can replicate that kind of performance this week.
Danny Welbeck - With Van Persie still struggling, the onus is maybe on Welbeck to lead the line again with Rooney. His movement and ability to create space for his teammates could be a decisive factor.
Last time they met
Manchester United 2-0 Everton, February 2013, Premier League
A routine victory for Manchester United as the opened up a 12 point lead at the top of the table and tightened their grip on the title race. Ryan Giggs opened the scoring after combining with Robin Van Persie to give the home side a 13th minute lead. Van Persie ended up doubling Manchester United's lead just before half-time after he raced on to a path from Rafael and then made it 2-0 despite the best efforts of John Heitinga to stop it on the line. The second half was quite tame as United were in complete control and cruised to victory, with Everton's hopes of a top four finish suffering a blow.