To be played on Sunday 1st December 2013 at 12:00. Venue: White Hart Lane, London.
Last season: 1-1
Preview & injury news
Preparation for this game hasn't been ideal for Andre Villas-Boas with many reports indicating that he is on borrowed time at White Hart Lane following a difficult run of league results which has seen them draw a blank in front of goal on each of their last three league outings. Spurs are currently ninth in the table, and despite a lot being written prematurely about their season, they are only four points off second place - which isn't a disaster for a side bidding to get into the Champions League this season.
Manchester United will have been disappointed with conceding a late goal away to Cardiff City, but have still picked up 14 points out of their last six games, meaning they are still in pretty good form - and are coming into this game on the back of qualifying for the knockout stages of the Champions League having dismantled Bayer Leverkusen - who sit in second place in the Bundesliga - 5-0 in their own backyard.
On the injury front Jan Vertonghen will still be expected to continue at left-back as Danny Rose continues to struggle with an ankle injury and is likely to be back in mid-December at the earliest. Emmanuel Adebayor has a groin injury after making a surprise return to the side in last week's hammering by Manchester City, and Christian Eriksen continues his recovery from an ankle injury he picked up on international duty two weeks ago.
For Manchester United, Robin Van Persie may be fit enough to play after missing the past two first team games. Nemanja Vidic may be part of the side after picking up concussion three weeks beforehand, whilst Rafael could be fit enough for selection. Michael Carrick still remains the big miss in United's squad for the lunchtime trip to White Hart Lane.
Roberto Soldado is Tottenham Hotspur's top scorer in the league with four goals this season.
Robin Van Persie is Manchester United's top scorer in the league with seven goals this season.
Tottenham Hotspur had 53% possession in their last league match, a 6-0 defeat away to Manchester City.
Manchester United had 50% possession in their last league match, a 2-2 draw away to Cardiff City.
5 players to watch
Roberto Soldado - Soldado has come in for a lot of criticism lately, and has been staunchly defended by his manager. With rumours surrounding the future of teammate Jermain Defoe, there's going to be an even bigger weight on the Spaniard's shoulders. A goal against Manchester United could make a massive difference for his Spurs career.
Robin Van Persie - Van Persie missed both last week's draw and the comfortable win over Bayer Leverkusen in the Champions League in midweek due to injury but he could be back for this weekend's trip to White Hart Lane. And coming up against a defence that conceded six last week, he might fancy adding to his Premier League goal tally.
Michael Dawson - Dawson needs to show some real leadership qualities going into this game. A game against the Champions was always going to be very difficult, but after conceding six the week before it could look like a daunting prospect. It's up to the skipper to sort his defence out and to try and lift morale.
Shinji Kagawa - Kagawa had a pretty good game in midweek against Leverkusen playing through the middle and David Moyes has said Kagawa should play more. Will he get a game on Sunday? And if he does, will it be through the middle again, or back on the left side?
Paulinho - A lot of these games are won in the middle of the park, meaning Paulinho is going to need to step up against Manchester United. Even without Carrick for Manchester United, expect the midfield to be a keenly contested part of the field.
Last time they met
Tottenham 1-1 Manchester United, Premier League, January 2013
Spurs were looking for a double over United but had to be content with a point. Robin Van Persie headed home a Tom Cleverley cross to put the visitors ahead on a snowy afternoon. Spurs had much of the play throughout the game but Sir Alex Ferguson was left furious after Wayne Rooney was brought down by Steven Caulker but no penalty was given. Rio Ferdinand and Nemanja Vidic had a solid display at the back but couldn't deny Clint Dempsey from scoring an injury time equaliser, preventing United from opening up a seven point gap at the top of the Premier League