Stories in the Spanish press have emerged that the Premier League champions will look to the Liga giants in January, and bid for two midfielders.
Barcelona-based newspaper El Mundo Deportivo have claimed that the Premier League champions will look to bolster their midfield in the winter transfer window by bidding for the Germany and Argentina internationals.
David Moyes’ men tried to sign a number of Liga-based midfielders during the summer, but failed in their attempts to bring in Cesc Fabregas, Luka Modric and Ander Herrera.
The Old Trafford team will go back to Spain however, and table offers for the Blancos pair, the Catalan daily has reported.
It claims United will offer €42m for Khedira, and €21m for Di Maria.
The former Stuttgart man has become an integral part of the Real Madrid team under Carlo Ancelotti, starting 11 League games. His contract expires in June 2015.
The ex-Benfica winger meanwhile, was heavily linked with a transfer away from Santiago Bernabeu, but stayed in the capital after Mesut Ozil left for Arsenal.
With Xabi Alonso's contract at Real Madrid up in the summer though, it seems unlikely that Los Merengues will want to let Khedira go for just £35m. A bid of over £40m though, may see him leave for the Premier League.
Asier Illarramendi was brought in from Real Sociedad in the summer as the next generation of defensive midfielder however, and has impressed with his recent, if admittedly fleeting, performances - and would be an able replacement for the 26-year-old.
Khedira was recently described as a 'jack of all trades' by the Spanish press, a testament to his usefulness in varying roles. He said at the start of the season he had been promised by Ancelotti he was very much needed and did not want to move on, and so is likely to want to stick the season out accordingly.
Di Maria may be easier to prize away from Ancelotti's team. Gareth Bale, Cristiano Ronaldo and Karim Benzema have formed a great attacking triumvirate at the start of this season, scoring 17 goals in the last four games.
And having flirted with a departure during pre-season, may be tempted to the north-west for more regular first-team action.
If he cannot force his way back into the team between now and January, Manchester United may find he is the player they find more value in pursuing.
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