12 months on the midfielder is still beset by fitness issues surrounding his ankle, and faces missing out on the crucial match next week.
Wilshere sat out Arsenal's win over Liverpool, and is expected not to travel to Germany with the Gunners' squad to face Dortmund in midweek.
There is further bad news however, with The Mirror reporting the midfielder as being a big doubt for Sunday's visit to Old Trafford.
"The midfielder suffered an injury to his OTHER ankle in training last week, which could also make him a big doubt to face Manchester United on Sunday, as well as play in England’s friendlies with Chile and Germany this month."
So what does this mean for Arsenal?
Ominously for Jack Wilshere, his absence from the team is not exactly a disaster nowadays.
Arsenal have become accustomed to winning without him, as evidenced by their stretch at the end of last season, and victory over Liverpool on Saturday.
Wilshere played in midweek against Chelsea in the Capital One Cup and was ineffective as the visitors won 2-0.
It is even questionable whether Wilshere even fits into Arsenal's best eleven at the moment.
Competition is fierce with Aaron Ramsey, Mathieu Flamini, Mikel Arteta, Tomas Rosicky and Santi Cazorla all battling for places.
In recent occasions, including the loss to Dortmund, Wilshere found himself shoved out onto the wing, in order to accommodate him.
Mathieu Flamini is hoping to be fit for the United game, a player Arsenal need far more at present than Wilshere.
Getting back to the form which makes his absence really bad news, has to be a priority for the midfielder, and staying fit is his first step in that challenge.
Are you concerned by Wilshere's absence?
image: © Ronnie Macdonald