The Togo international forward has travelled with the squad to face FC Sheriff in Moldova, and could make his first appearance of the season.
After a busy summer in the transfer window, Tottenham can boast one of the most comprehensive squads in the Premier League.
Such is the strength in depth and competition for places that a certain Emmanuel Adebayor has been rotting away in the reserves, not getting a look-in.
A player that has cost Premier League clubs over £30 million in transfer fees over the years, Adebayor is also thought be one of Tottenham’s top earners.
After a disrupted pre-season and the summer addition of Roberto Soldado, the African attacker has been deemed surplus to requirements.
"He travelled. There is a chance he could be involved, but I'm not sure if he's starting or not,” the Portuguese manager said.
“They don't need opportunities or chances. They're valued and they're great quality players.”
When discussing Adebayor and other fringe players that could get a chance to play tonight, Villas-Boas conceded that there was a chance for some to impress and stake their claim for more regular inclusion.
"This is done because of the immense talent we have at our disposal," he said.
"We can make six or seven changes now, which keeps the players fresh and motivated.
"There is always that chance they can break into the team, although both are established players and have been successful in the past."
For Adebayor, there is every chance that he could get back into the first-team reckoning if he can get close to match fitness and back to his best.
His first season at White Hart Lane, when he was on loan from Manchester City, Adebayor was deemed by many as the answer to Spurs’ long-standing striker dilemma.
An inconsistent season last term prompted the signing of Soldado, but towards the end of the campaign Adebayor showed that he still has what it takes to be a top Premier League striker.
With the Togolese attacker unlikely to leave White Hart Lane anytime soon due to suitors not being able to match his current salary, Villas-Boas is wise to use him in the cup competitions.
With Soldado yet to completely convince the Spurs faithful or justify his transfer fee and Defoe seemingly a perennial substitute, there is a window of opportunity for Adebayor.
If he can get back to his best in the cup competitions it will strengthen the predominantly second-string side, give AVB another option and also make the other strikers work harder for their place in the first-team.
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