All of the English teams are doing well in the competition so far, with Manchester United the only side struggling although they are only three points off the top of their group after just two games.
Arsenal play Borussia Dortmund, Chelsea face FC Schalke, Manchester City are away at CSKA Moscow and Manchester United host Real Sociedad as each team looks to secure another vital three points.
Arsenal v Borussia Dortmund
Arsenal sit top of Group F impressively after two games with eight goals scored and just two conceded so far.
They should be extremely confident because they go into this game after consecutive European wins and they are one of two sides with an unbeaten record in the Under-21 Premier League.
Dortmund will not be pushovers but they have been inconsistent in the tournament so far with a win and a defeat from their two games.
FC Schalke v Chelsea
Schalke against Chelsea could be the match of the round because both teams have exactly the same record from games so far; two wins, eight goals scored and not a single goal conceded.
Chelsea secured a 2-2 draw away at Sunderland over the weekend and they should take confidence from the fact that only Liverpool and Newcastle United have scored more goals in the Under-21 Premier League.
Schalke may be slightly damaged from injuries to the senior side, which may see some of their stronger youth team players called up and subsequently unavailable.
CSKA Moscow v Manchester City
Manchester City are the enigma of this competition so far.
They have two wins from two and they took Bayern Munich apart in their last game winning 6-0. They also boast impressive stats of ten goals scored and just one conceded so far in the competition.
However, domestically Patrick Vieira’s men have struggled and sit joint bottom of the Premier League having lost four of their opening six fixtures.
Manchester United v Real Sociedad
Manchester United face a very difficult task against Group A leaders Real Sociedad.
United currently sit third following a narrow defeat to Shakhtar Donetsk in their last game.
Sociedad have been decent in both attack and defence this season with eight goals scored and three conceded, while United have a level goal difference with five goals scored and conceded.
A solid win for United in this game will put them second unless they overhaul the plus five goal difference of their Spanish opponents.
image: © jorge-11