After the weekend's result, getting as far away from Old Trafford as possible may seem in theory a good idea for Manchester United.
But we are not sure that travelling to the Ukraine is exactly what the club would have in mind.
Despite selling Mkhitaryan and Fernandinho for huge profits this summer, they remain a club packed with stars - including Brazilian pair Douglas Costa and Bernard.
Perhaps the most intriguing man in their line-up is former Arsenal striker Eduardo da Silva.
Eduardo is a player who once haunted England with Croatia, and began his Gunners career with a terrific strike ate - before suffering a broken leg against Birmingham City which sparked a William Gallas-led title meltdown.
While he recovered to physical fitness, the striker admitted he was not mentally over the incident and needed to move elsewhere to get past it.
Step forward Shakhtar Donetsk where he has been ever since, even scoring a winner against the Gunners soon after moving to the Ukraine in a Champions League match.
Donetsk have a fearful home record at the Donbass Arena, with Chelsea also suffering defeat there last season in the Champions League group stages.
Eduardo has played more than 70 games for the club, although his scoring record has slowed, netting 21 in total during that period - often featuring as a substitute or even out wide.
This season his scoring record has echoed that ratio, scoring twice in seven matches. But the second of those came at the weekend in a 2-2 derby draw against Metalurgs Donetsk.
He will certainly have given his coach food for thought, having been left out of Shakhtar's 2-0 opened loss away at Real Sociedad, a change of line-up is likely.
Shakhtar need to win to keep their hopes of qualification realistic, heading into the double header against Leverkusen, and the extra motivation will be a real test for David Moyes as he leads Manchester United into their first away game under his management.
On Saturday August 15 2009, Moyes watched on painfully as Arsenal demolished his Everton side - It was Eduardo who struck the sixth.
Few would bet on a result like that, but just seeing the striker in action might just bring back bad memories for United's manager. He will hope he can avoid him etching any more into his mind.
image: © wonker