Bradford City enjoyed a remarkable Capital One Cup adventure last season, knocking out Wigan, Arsenal and Aston Villa on the way to the final, and teams will have paid note of their achievements.
One 'shock' has already taken place, with League One side Preston triumphing 1-0 over Championship club Blackpool last night.
So who can emulate them and pull off a shock? We have taken a look through tonight's fixtures and picked out five games which have potential upset written on the cards...
Exeter v QPR
Both sides had positive starts to the season at the weekend, each registering 2-1 wins. League Two side Exeter have claimed they have 'nothing to lose' heading into the tie, and they are right, which places all the pressure on QPR, a side who were in the Premier League this time last year. Harry Redknapp is likely to rotate his squad, but he needs to strike the right balance and ensure his players understand just what a tough away game they are likely to be in for.
Morecambe v Wolves
Wolves are still coming to terms with their League One status after back-to-back relegations, and new manager Kenny Jackett will not want the embarrassment of a cup upset early into his tenure. A 0-0 draw with Preston at the weekend was not the worst of starts, but a win will be needed here against a League Two Morecambe side who lost 1-0 to Wycombe in their opener. This will be their first home game of the season, and they will want to deliver an upset to kickstart their campaign.
Stevenage v Ipswich
Mick McCarthy's Ipswich side lost 2-1 to Reading at the weekend, and now travel to a Stevenage team who also suffered a narrow defeat, going down 4-3 at home to Oldham in their opener. Stevenage have seen Tottenham visit in recent seasons and won't be daunted by the visit of Ipswich, just one division above.
Brighton v Newport
Brighton still have the off-field Gus Poyet saga as an unwelcome distraction, and suffered a late 2-1 defeat to Leeds in their Championship opener. They go up against a confident newly promoted League Two side in Newport, who posted a stunning 4-1 win against Accrington. They will hold no fear upon their trip to the Amex Stadium. This one could be full of goals.
Millwall v Wimbledon
Millwall could have been relegated on the final day last season had results not gone their way, and got this season off to a poor start, losing 1-0 to Championship new boys Yeovil. So they will be keen to avoid a cup defeat at home to AFC Wimbledon, who posted a 1-1 draw in their season opener in League Two against Torquay.
Where do you see upsets happening tonight? Any of the above?
image: © martinrp