Vertonghen picked up the knock during Tottenham’s 3-1 defeat to Sunderland in the Premier League Asia Trophy which has now given Andre Villas-Boas a massive headache, which for once has nothing to do with Gareth Bale.
The Belgian was one of Spurs’ most consistent defenders last season and his possible absence from the side for the start of the season could force AVB down one of many different lines of thinking.
Fortunately for the club Younes Kaboul has just returned from a long term injury, which means the club has cover in the centre of defence and will boast a very strong partnership of Kaboul and Michael Dawson at the start of the Premier League campaign.
Steven Caulker also played some solid football last season, which means there is a little bit of cover in place but outside of him, Spurs are short in central defence after the release of the experienced William Gallas.
AVB still has time to get reinforcements in whether he wants to go out and sign another defensive player or he could choose to promote a player from the youth teams of the club.
There is also the possibility that one of the more defensive players in the Tottenham midfield could drop back into the defence, which is a tactic that several managers have used before.
It’s a big blow to Spurs also because of Vertonghen’s versatility and how comfortably he can also play at full back, offering the boss different options if he needs to use the 26-year-old in that role.
It all depends on how well Vertonghen responds to treatment and the fact the injury is just a sprain rather than a tear is positive news.
Tottenham’s first Premier League game is against Crystal Palace on August 18, which gives him a little over three weeks from now to undergo treatment and then get back into the swing of things before competitive action.
However, the fact he’s picked up this knock in pre-season means when he does get over the sprain and is able to return to training, he’s still going to be a little behind his teammates in terms of where his fitness should be.
After all, pre-season is all about getting minutes under the belt to reach a level of physical fitness which allows players to be competitive late into games when the competitive action starts.
Spurs will want their very best eleven fit and available for selection by the time that first Premier League game comes round because this is a huge season for the club as they look to break into and then consolidate as a top four team.
How much of a blow do you think it will be to Spurs if Vertonghen misses the start of the season?