Hughes was Blackburn's manager when Samba signed from Hertha Berlin for £450,000 in January 2007, and is keen to be reunited with a player he believes can make a big difference for a Fulham side struggling in 18th position.
Samba went public with his desire to leave Ewood Park after the club's new owners, the Venky's Group, sacked Sam Allardyce this month. Steve Kean, Allardyce's replacement, has since reported that Samba has changed his mind but Hughes believes he can attract a player who represents one of his more astute pieces of transfer business.
Hughes is also mulling over a move for another of his former players, Manchester City's unwanted striker Roque Santa Cruz, but has reservations about pinning his hopes on a player with such a persistent injury record.
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